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Simplifying RNA QC: Can Carbon-Based Digital Liquid Chromatography Help?
RNA therapeutics require characterization of up to 20 critical quality attributes, which currently demands multiple dedicated LC methods — reversed-phase, anion-exchange, and size-exclusion — on separate instruments. Carbon-based digital liquid chromatography offers a different direction. By applying voltage to an all-carbon conductive stationary phase, retention can be tuned in real time. We explore how this approach may consolidate RNA QC workflows into a single compact pla
May 15


Digital Liquid Chromatography with All‑Carbon Microbeads: Applications in Sample Cleanup, PFAS, Multi‑Omics, and RNA QC
Electrochemically modulated liquid chromatography (EMLC), also called digital liquid chromatography, uses applied voltage to dynamically tune analyte retention on all-carbon microbeads. This voltage-tunable platform enables smarter sample cleanup, selective PFAS capture, streamlined multi-omics workflows, and RNA critical quality attribute testing. All on one conductive stationary phase. Explore how Millennial Scientific's all-carbon EMLC platform is advancing separations acr
May 14


From Benchmarking to Batch Release: Validating an RP-HPLC Method for GLP-1 Peptides on All-Carbon Microbeads
A validated RP-HPLC method for semaglutide and liraglutide on NanoPak-C all-carbon microbeads demonstrates R² > 0.99 linearity, LOD as low as 0.0024 mg/mL, and system precision below 2% %RSD — all at pH 8.5. We explain what each validation parameter means for QC labs, why liraglutide data extends the platform, and how this ICH Q2(R1)-compliant method is ready for regulatory submissions and multi-site method transfer.
Mar 6
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