Bridging analytical and preparative HPLC, this blog shows how NanoPak‑C all‑carbon columns withstand tens of thousands of column volumes at pH 8.5 in GLP‑1 methods. By expressing alkaline-pH exposure in column volumes, we model NanoPak‑C stability for scale-up from analytical to semi‑prep and prep purification of Semaglutide, Liraglutide, and other peptide drugs.

Flash chromatography is a valuable tool in peptide purification workflows, especially as a pre-purification or cleanup step.

The aggregation or clumping of peptides and proteins is a crucial phenomenon in biology , influenced by various factors [1]....

This blog is part of our separation science primer series which provides an easy-to-understand overview of key topics in solid-phase...