Bridging analytical and preparative HPLC, this blog shows how NanoPak‑C all‑carbon columns withstand tens of thousands of column volumes at pH 8.5 in GLP‑1 methods. By expressing alkaline-pH exposure in column volumes, we model NanoPak‑C stability for scale-up from analytical to semi‑prep and prep purification of Semaglutide, Liraglutide, and other peptide drugs.

A validated RP-HPLC method for semaglutide and liraglutide on NanoPak-C all-carbon microbeads demonstrates R² > 0.99 linearity, LOD as low as 0.0024 mg/mL, and system precision below 2% %RSD — all at pH 8.5. We explain what each validation parameter means for QC labs, why liraglutide data extends the platform, and how this ICH Q2(R1)-compliant method is ready for regulatory submissions and multi-site method transfer.

A pharmaceutical's purity, assay, and potency are terms commonly used when discussing drug quality testing. Due to its accuracy and...

Millennial Scientific is pleased to announce a major achievement in our product development: the successful completion of the beta...

pH-dependent aggregation behavior of peptides. In a previous blog post, we delved into the complex issue of peptide and protein...

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We have published an application note that presents an optimized method for HPLC separation of semaglutide and liraglutide. This method...